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Figure Focus Key Elements 1 The Dynamic Tumor ECM Schematic of ECM composition and remodeling in normal vs. tumor tissue; highlight sources (fibroblasts, CAFs, cancer cells), key proteins (collagen, fibronectin, tenascin), and enzymes (MMPs, LOX). 2 ECM-Mediated Pathways to Invasion and Metastasis Diagram showing how ECM stiffness, degradation, and biochemical signaling drive invasion, immune evasion, and metastatic niche formation; include therapeutic intervention points.

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